Genetic Variation and Atherosclerosis

Genetic Variation and Atherosclerosis

A family history of atherosclerosis is independently associated with an increased incidence of cardiovascular events. The genetic factors underlying the importance of inheritance in atherosclerosis are starting to be understood. Genetic variation, such as mutations or common polymorphisms has been shown to be involved in modulation of a range of risk factors, such as plasma lipoprotein levels, ...

Association of Mitochondrial Genetic Variation with Carotid Atherosclerosis

In human pathology, several diseases are associated with somatic mutations in the mitochondrial genome (mtDNA). Even though mitochondrial dysfunction leads to increased oxidative stress, the role of mitochondrial mutations in atherosclerosis has not received much attention so far. In this study we analyzed the association of mitochondrial genetic variation with the severity of carotid atheroscl...

Genetic Variation in MMP-1 Promoter Region and

Genetic Susceptibility to Atherosclerosis

Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic ground significantly influences susceptibility to atherosclerotic vascular diseases. Besides further investigations of monogenetic diseases, candidate genes, genetic polymorphisms, and susceptibilit...

genetic variation and genetic gain from selection in bread wheat

genetic variation is necessary factor for continued breeding and increasing genetic gain from selection in crop plants. to evaluate genetic variation and genetic gain from selection in bread wheat, 45 genotypes consisting of 9 cultivars and their 36 crosses were grown in a randomized complete block design with three replications in research farm of isfahan university of technology. the phenotyp...